Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the
production of type I interferons (IFNs). pDCs promote antiviral immune responses and have …

Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …

Dendritic cells (DCs) are professional antigen presenting cells (APCs) that originate in the
bone marrow and are continuously replenished from hematopoietic progenitor cells …

Autoimmune thyroid disease is the most common autoimmune disease and is highly
heritable. Here, by using a genome-wide association study of 30,234 cases and 725,172 …

T cell specification and commitment require Notch signaling. Although the requirement for
Notch signaling during intrathymic T cell development is known, it is still unclear whether the …

Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from
progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in …

Dendritic cells (DCs) are major regulators of adaptive immunity, as they are not only capable
to induce efficient immune responses, but are also crucial to maintain peripheral tolerance …

Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and
adaptive immunity. They sense viral and bacterial pathogens and release high levels of …

Dendritic cells (DCs) and monocytes develop from a series of bone-marrow–resident
progenitors in which lineage potential is regulated by distinct transcription factors. Zeb2 is an …

Low capacity to produce ROS because of mutations in neutrophil cytosolic factor 1
(NCF1/p47phox), a component of NADPH oxidase 2 (NOX2) complex, is strongly associated …