Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
[HTML][HTML] Functions of N6-methyladenosine and its role in cancer
L He, H Li, A Wu, Y Peng, G Shu, G Yin - Molecular cancer, 2019 - Springer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment
N Li, Y Kang, L Wang, S Huff, R Tang… - Proceedings of the …, 2020 - National Acad Sciences
Although immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment,
many patients do not respond or develop resistance to ICB. N6-methylation of adenosine …
many patients do not respond or develop resistance to ICB. N6-methylation of adenosine …
YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7
J Pi, W Wang, M Ji, X Wang, X Wei, J Jin, T Liu, J Qiang… - Cancer research, 2021 - AACR
Abstract N6-methyladenosine (m6A) is the most prevalent internal RNA modification in
mammals that regulates homeostasis and function of modified RNA transcripts. Here, we …
mammals that regulates homeostasis and function of modified RNA transcripts. Here, we …
[HTML][HTML] METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications
D Jian, Y Wang, L Jian, H Tang, L Rao, K Chen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Aims: The N6-methyladenosine (m 6 A) modification plays an important role in various
biological processes, but its role in atherosclerosis remains unknown. The aim of this study …
biological processes, but its role in atherosclerosis remains unknown. The aim of this study …
[HTML][HTML] Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a
Y Xu, Z Zhou, X Kang, L Pan, C Liu, X Liang… - Nature …, 2022 - nature.com
Hepatic specification and functional maturation are tightly controlled throughout
development. N6-methyladenosine (m6A) is the most abundant RNA modification of …
development. N6-methyladenosine (m6A) is the most abundant RNA modification of …
[HTML][HTML] scm6A-seq reveals single-cell landscapes of the dynamic m6A during oocyte maturation and early embryonic development
H Yao, CC Gao, D Zhang, J Xu, G Song, X Fan… - Nature …, 2023 - nature.com
Abstract N 6-methyladenosine (m6A) has been demonstrated to regulate RNA metabolism
and various biological processes, including gametogenesis and embryogenesis. However …
and various biological processes, including gametogenesis and embryogenesis. However …
[HTML][HTML] RNA methylation in mammalian development and cancer
P Song, S Tayier, Z Cai, G Jia - Cell Biology and Toxicology, 2021 - Springer
Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA
modifications) have emerged as crucial regulators in temporal and spatial gene expression …
modifications) have emerged as crucial regulators in temporal and spatial gene expression …
Emerging roles of RNA methylation in development
MK Wang, CC Gao, YG Yang - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus More than 170 different types of chemical modifications have been identified on
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …
diverse types of RNA, collectively known as the epitranscriptome. Among them, N 6 …
The m6A Writer: Rise of a Machine for Growing Tasks
DL Balacco, M Soller - Biochemistry, 2018 - ACS Publications
The central dogma of molecular biology introduced by Crick describes a linear flow of
information from DNA to mRNA to protein. Since then it has become evident that RNA …
information from DNA to mRNA to protein. Since then it has become evident that RNA …