The 'Gab'in signal transduction
H Gu, BG Neel - Trends in cell biology, 2003 - cell.com
Tyrosine phosphorylation plays an important role in controlling cellular growth,
differentiation and function. Abnormal regulation of tyrosine phosphorylation can result in …
differentiation and function. Abnormal regulation of tyrosine phosphorylation can result in …
The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3
Ligation of the T cell receptor for antigen (TCR) and/or costimulatory receptor CD28 results
in rapid activation of phosphoinositide‐3 kinase (PI‐3 kinase). It remains unclear, however …
in rapid activation of phosphoinositide‐3 kinase (PI‐3 kinase). It remains unclear, however …
The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination
Tuberculosis remains the world's leading cause of death due to a single infectious agent,
Mycobacterium tuberculosis, with 3 million deaths and 10 million new cases per year. The …
Mycobacterium tuberculosis, with 3 million deaths and 10 million new cases per year. The …
GAB2 alleles modify Alzheimer's risk in APOE ɛ4 carriers
The apolipoprotein E (APOE) ɛ4 allele is the best established genetic risk factor for late-
onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single …
onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single …
Critical role for Gab2 in transformation by BCR/ABL
The BCR/ABL oncogene causes chronic myelogenous leukemia (CML) in humans and a
CML-like disease, as well as lymphoid leukemia, in mice. p210 BCR/ABL is an activated …
CML-like disease, as well as lymphoid leukemia, in mice. p210 BCR/ABL is an activated …
Essential role for Gab2 in the allergic response
H Gu, K Saito, LD Klaman, J Shen, T Fleming… - Nature, 2001 - nature.com
Dos/Gab family scaffolding adapters (Dos, Gab1, Gab2) bind several signal relay molecules,
including the protein-tyrosine phosphatase Shp-2 and phosphatidylinositol-3-OH kinase (PI …
including the protein-tyrosine phosphatase Shp-2 and phosphatidylinositol-3-OH kinase (PI …
Function, regulation and pathological roles of the Gab/DOS docking proteins
FU Wöhrle, RJ Daly, T Brummer - Cell Communication and Signaling, 2009 - Springer
Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS
family have emerged as important signalling elements in metazoans. Gab/DOS proteins …
family have emerged as important signalling elements in metazoans. Gab/DOS proteins …
The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors
The Grb2‐associated binder (Gab) family adapter proteins are scaffolding adapter
molecules that display sequence similarity with Drosophila DOS (daughter of sevenless) …
molecules that display sequence similarity with Drosophila DOS (daughter of sevenless) …
Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis
F Català-Moll, AG Ferreté-Bonastre, G Godoy-Tena… - Cell reports, 2022 - cell.com
The active form of vitamin D, 1, 25-dihydroxyvitamin D3, induces a stable tolerogenic
phenotype in dendritic cells (DCs). This process involves the vitamin D receptor (VDR) …
phenotype in dendritic cells (DCs). This process involves the vitamin D receptor (VDR) …
De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and …
The large yellow croaker (Pseudosciaena crocea) is an economically important marine fish
in China. To understand the molecular basis for antiviral defense in this species, we used …
in China. To understand the molecular basis for antiviral defense in this species, we used …