Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …
functioning associated with the disorder and are not responsive to existing treatments. In this …
[HTML][HTML] Improving the study of brain-behavior relationships by revisiting basic assumptions
Neuroimaging research has been at the forefront of concerns regarding the failure of
experimental findings to replicate. In the study of brain-behavior relationships, past failures …
experimental findings to replicate. In the study of brain-behavior relationships, past failures …
[HTML][HTML] Linking structure and function in macroscale brain networks
Structure–function relationships are a fundamental principle of many naturally occurring
systems. However, network neuroscience research suggests that there is an imperfect link …
systems. However, network neuroscience research suggests that there is an imperfect link …
Schizophrenia—an overview
RA McCutcheon, TR Marques, OD Howes - JAMA psychiatry, 2020 - jamanetwork.com
Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …
encounter regularly during their practice. This report provides an overview of the clinical …
[HTML][HTML] The quest for multiscale brain modeling
E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …
repertoire of the organ, remains challenging. In principle, it should be possible to model …
Inversion of a large-scale circuit model reveals a cortical hierarchy in the dynamic resting human brain
We considered a large-scale dynamical circuit model of human cerebral cortex with region-
specific microscale properties. The model was inverted using a stochastic optimization …
specific microscale properties. The model was inverted using a stochastic optimization …
Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: recommendations of an expert panel
Abstract The Electrophysiology Professional Interest Area (EPIA) and Global Brain
Consortium endorsed recommendations on candidate electroencephalography (EEG) …
Consortium endorsed recommendations on candidate electroencephalography (EEG) …
[HTML][HTML] The scientific case for brain simulations
A key element of the European Union's Human Brain Project (HBP) and other large-scale
brain research projects is the simulation of large-scale model networks of neurons. Here, we …
brain research projects is the simulation of large-scale model networks of neurons. Here, we …
[HTML][HTML] Concurrent TMS-fMRI for causal network perturbation and proof of target engagement
TO Bergmann, R Varatheeswaran, CA Hanlon… - Neuroimage, 2021 - Elsevier
The experimental manipulation of neural activity by neurostimulation techniques overcomes
the inherent limitations of correlative recordings, enabling the researcher to investigate …
the inherent limitations of correlative recordings, enabling the researcher to investigate …
Learning how network structure shapes decision-making for bio-inspired computing
To better understand how network structure shapes intelligent behavior, we developed a
learning algorithm that we used to build personalized brain network models for 650 Human …
learning algorithm that we used to build personalized brain network models for 650 Human …