[HTML][HTML] Antibiotics: past, present and future
The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have
drastically changed modern medicine and extended the average human lifespan by 23 …
drastically changed modern medicine and extended the average human lifespan by 23 …
Ecology and genomics of Actinobacteria: new concepts for natural product discovery
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
Soil biodiversity supports the delivery of multiple ecosystem functions in urban greenspaces
While the contribution of biodiversity to supporting multiple ecosystem functions is well
established in natural ecosystems, the relationship of the above-and below-ground diversity …
established in natural ecosystems, the relationship of the above-and below-ground diversity …
Global homogenization of the structure and function in the soil microbiome of urban greenspaces
M Delgado-Baquerizo, DJ Eldridge, YR Liu… - Science …, 2021 - science.org
The structure and function of the soil microbiome of urban greenspaces remain largely
undetermined. We conducted a global field survey in urban greenspaces and neighboring …
undetermined. We conducted a global field survey in urban greenspaces and neighboring …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
[HTML][HTML] Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens
BM Hover, SH Kim, M Katz, Z Charlop-Powers… - Nature …, 2018 - nature.com
Despite the wide availability of antibiotics, infectious diseases remain a leading cause of
death worldwide 1. In the absence of new therapies, mortality rates due to untreatable …
death worldwide 1. In the absence of new therapies, mortality rates due to untreatable …
Disease-suppressive soils—beyond food production: a critical review
In the pursuit of higher food production and economic growth and increasing population, we
have often jeopardized natural resources such as soil, water, vegetation, and biodiversity at …
have often jeopardized natural resources such as soil, water, vegetation, and biodiversity at …
Bacterial secondary metabolite biosynthetic potential in soil varies with phylum, depth, and vegetation type
Bacteria isolated from soils are major sources of specialized metabolites, including
antibiotics and other compounds with clinical value that likely shape interactions among …
antibiotics and other compounds with clinical value that likely shape interactions among …
Secondary metabolism in the lichen symbiosis
MJ Calcott, DF Ackerley, A Knight… - Chemical Society …, 2018 - pubs.rsc.org
Lichens, which are defined by a core symbiosis between a mycobiont (fungal partner) and a
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …
Biodiversity of urban soils for sustainable cities
C Guilland, PA Maron, O Damas, L Ranjard - Environmental chemistry …, 2018 - Springer
The last century was marked by a high demographic revolution and the fast development of
urban environments. Now, more than 50% of the world's 7.5 billion humans live in cities …
urban environments. Now, more than 50% of the world's 7.5 billion humans live in cities …