[HTML][HTML] Antibiotics: past, present and future

MI Hutchings, AW Truman, B Wilkinson - Current opinion in microbiology, 2019 - Elsevier
The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have
drastically changed modern medicine and extended the average human lifespan by 23 …

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Soil biodiversity supports the delivery of multiple ecosystem functions in urban greenspaces

K Fan, H Chu, DJ Eldridge, JJ Gaitan, YR Liu… - Nature Ecology & …, 2023 - nature.com
While the contribution of biodiversity to supporting multiple ecosystem functions is well
established in natural ecosystems, the relationship of the above-and below-ground diversity …

Global homogenization of the structure and function in the soil microbiome of urban greenspaces

M Delgado-Baquerizo, DJ Eldridge, YR Liu… - Science …, 2021 - science.org
The structure and function of the soil microbiome of urban greenspaces remain largely
undetermined. We conducted a global field survey in urban greenspaces and neighboring …

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

[HTML][HTML] Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

BM Hover, SH Kim, M Katz, Z Charlop-Powers… - Nature …, 2018 - nature.com
Despite the wide availability of antibiotics, infectious diseases remain a leading cause of
death worldwide 1. In the absence of new therapies, mortality rates due to untreatable …

Disease-suppressive soils—beyond food production: a critical review

S Jayaraman, AK Naorem, R Lal, RC Dalal… - Journal of Soil Science …, 2021 - Springer
In the pursuit of higher food production and economic growth and increasing population, we
have often jeopardized natural resources such as soil, water, vegetation, and biodiversity at …

Bacterial secondary metabolite biosynthetic potential in soil varies with phylum, depth, and vegetation type

AM Sharrar, A Crits-Christoph, R Méheust, S Diamond… - MBio, 2020 - Am Soc Microbiol
Bacteria isolated from soils are major sources of specialized metabolites, including
antibiotics and other compounds with clinical value that likely shape interactions among …

Secondary metabolism in the lichen symbiosis

MJ Calcott, DF Ackerley, A Knight… - Chemical Society …, 2018 - pubs.rsc.org
Lichens, which are defined by a core symbiosis between a mycobiont (fungal partner) and a
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …

Biodiversity of urban soils for sustainable cities

C Guilland, PA Maron, O Damas, L Ranjard - Environmental chemistry …, 2018 - Springer
The last century was marked by a high demographic revolution and the fast development of
urban environments. Now, more than 50% of the world's 7.5 billion humans live in cities …