Inflammation and skeletal muscle wasting during cachexia

JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Cancer cachexia: molecular mechanisms and treatment strategies

T Setiawan, IN Sari, YT Wijaya, NM Julianto… - Journal of Hematology & …, 2023 - Springer
Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

Nutrition interventions to treat low muscle mass in cancer

CM Prado, SA Purcell, A Laviano - Journal of cachexia …, 2020 - Wiley Online Library
Many patients with cancer experience poor nutritional status, which detrimentally impacts
clinical outcomes. Poor nutritional status in cancer is primarily manifested by severe muscle …

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

S Peixoto da Silva, JMO Santos… - Journal of cachexia …, 2020 - Wiley Online Library
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …

The role of tumor microenvironment cells in colorectal cancer (CRC) cachexia

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions

JA Siddiqui, R Pothuraju, M Jain, SK Batra… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Advanced cancer patients exhibit cachexia, a condition characterized by a significant
reduction in the body weight predominantly from loss of skeletal muscle and adipose tissue …

LncRNA-mediated adipogenesis in different adipocytes

P Zhang, S Wu, Y He, X Li, Y Zhu, X Lin… - International Journal of …, 2022 - mdpi.com
Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely
present in eukaryotes. They regulate gene expression at multiple levels through different …

[HTML][HTML] GDF15/GFRAL pathway as a metabolic signature for cachexia in patients with cancer

DS Ahmed, S Isnard, J Lin, B Routy, JP Routy - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Cachexia is a metabolic mutiny that directly reduces life expectancy in chronic conditions
such as cancer. The underlying mechanisms associated with cachexia involve inflammation …

Adipocytes in breast cancer, the thick and the thin

I Rybinska, R Agresti, A Trapani, E Tagliabue, T Triulzi - Cells, 2020 - mdpi.com
It is well established that breast cancer development and progression depend not only on
tumor-cell intrinsic factors but also on its microenvironment and on the host characteristics …

Relevance of dietary supplement use in gastrointestinal-Cancer-associated Cachexia

SL Yoon, O Grundmann - Nutrients, 2023 - mdpi.com
Cancer cachexia is a multi-organ syndrome with unintentional weight loss, sarcopenia, and
systemic inflammation. Gastrointestinal (GI) cancer patients are more susceptible to …