The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

Convection-enhanced delivery (CED) is a promising technique that generates a pressure
gradient at the tip of an infusion catheter to deliver therapeutics directly through the …

Patterns of spontaneous brain activity, typically measured in humans at rest with fMRI, are
used routinely to assess the brain's functional organization. The mechanisms that generate …

Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …

Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit
direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while …

Objective To investigate the safety and tolerability of convection‐enhanced delivery of an
adeno‐associated virus, serotype‐2 vector carrying glial cell line‐derived neurotrophic …

Both hypoactivity and hyperactivity in the amygdala are associated with perturbations in
social behavior. While> 60 years of experimental manipulations of the amygdala in animal …

OBJECTIVE Progress in management of high-grade gliomas (HGGs) has been hampered
by poor access of potential therapeutics to the CNS. The Cleveland Multiport Catheter …

Stimulation of the intermediate and deep layers of superior colliculus (DLSC) in rodents
evokes both orienting/pursuit (approach) and avoidance/flight (defense) responses. These …

Brain drug delivery is a major challenge for therapy of central nervous system (CNS)
diseases. Biochemical modifications of drugs or drug nanocarriers, methods of local …