For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Chemokines are a class of small cytokines or signaling proteins that are secreted by cells.
Owing to their ability to induce directional chemotaxis of nearby responding cells, they are …

Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …

The spleen is a gatekeeper of systemic immunity where immune responses against blood-
borne pathogens are initiated and sustained. Non-haematopoietic stromal cells construct …

We assessed a cohort of people living with human immunodeficiency virus (PLWH)(n= 110)
and HIV negative controls (n= 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all …

During chronic antigen exposure, a subset of exhausted CD8+ T cells differentiate into stem
cell-like or progenitor-like T cells expressing both transcription factor Tcf-1 (T cell factor-1) …

Simple Summary Thermal ablation has been confirmed to increase the percentage of
functional CD8+ T cells in the tumor microenvironment (TME) and activate tumor-specific T …

Antigen-presenting cells (APCs) are pivotal mediators of immune responses. Their role has
increasingly been spotlighted in the realm of cancer immunology, particularly as our …

Objectives Besides CD4 regulatory T-cells (Tregs), immunosuppressor FoxP3+ CD8 T-cells
are emerging as an important subset of Tregs, which contribute to immune dysfunction and …

Pancreatic ductal adenocarcinoma (PDA) is a lethal and metastatic malignancy resistant to
therapy. Elucidating how pancreatic tumor-specific T cells differentiate and are maintained in …