Mitochondria possess a Ca 2+ transport system composed of separate Ca 2+ influx and
efflux pathways. Intramitochondrial Ca 2+ concentrations regulate oxidative …

In their reductionist approach in unraveling phenomena inside the cell, scientists in recent
times have focused attention to mitochondria. An organelle with peculiar evolutionary history …

Modulation of tumor-associated macrophages (TAMs) holds promise for cancer treatment,
mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the …

Intracellular redox homeostasis and the iron metabolism system in tumor cells are closely
associated with the limited efficacy of chemodynamic therapy (CDT). Despite extensive …

Introduction: Alzheimer's disease is primarily a dementia-related disorder from progressive
cognitive deterioration and memory impairment, while Parkinson's disease is primarily a …

Iron is an essential element for human life. However, it is a pro-oxidant agent capable of
reacting with hydrogen peroxide. An iron overload can cause cellular changes, such as …

Excess extracellular glutamate, the main excitatory neurotransmitter, may result in
excitotoxicity and neural injury. The present study was designed to study the effect of …

The aims of this study were to measure oxidative stress parameters and to investigate the
molecular mechanism triggered by grain-induced subacute ruminal acidosis in mid-lactation …

Beauvericin (BEA) and enniatin B (ENNB) are emerging mycotoxins frequently detected in
plant-based fish feed. With ionophoric properties, they have shown cytotoxic potential in …

OBJECTIVE: Beside matrix metalloproteinases, reactive oxygen species (ROS) are the main
biochemical factors of cartilage degradation. To prevent ROS toxicity, chondrocytes possess …