Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO)
has been neglected for many years, and only recently has its role as an essential signaling …

Carbon monoxide (CO) has been regarded as a “silent killer” for its toxicity toward biological
systems. However, a low concentration of endogenously produced CO has shown a number …

Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …

Significance: Heme degradation, which was described more than 30 years ago, is still very
actively explored with many novel discoveries on its role in various disease models every …

BACKGROUND. Acute respiratory distress syndrome (ARDS) is a prevalent disease with
significant mortality for which no effective pharmacologic therapy exists. Low-dose inhaled …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …