Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …

Human γ-secretase is an intra-membrane protease that cleaves many different substrates.
Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid …

Summary γ-secretase catalyzes the intramembrane cleavage of amyloid precursor protein
(APP) and Notch after their extracellular domains are shed by site-specific proteolysis …

Helical integral membrane proteins share several structural determinants that are widely
conserved across their universe. The discovery of common motifs has furthered our …

Processing of the amyloid precursor protein (APP) by β‐and γ‐secretases leads to the
generation of amyloid‐β (Aβ) peptides with varying lengths. Particularly Aβ42 contributes to …

The Notch signaling pathway, which is highly conserved from sea urchins to humans, plays
an important role in cell-differentiation, survival, proliferation, stem-cell renewal, and …

Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The
degradome of these aspartyl proteases consists of at least 60 different substrates. γ …

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease of the pilosebaceous
unit, clinically consisting of painful nodules, abscesses, and sinus tracts mostly in, but not …

Abstract γ-Secretase catalyzes the final cleavage of the β-amyloid precursor protein to
generate amyloid-β peptide, the principal component of amyloid plaques in the brains of …