• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Staphylococcus aureus is a microorganism frequently associated with implant-related
infections, owing to its ability to produce biofilms. These infections are difficult to treat …

Staphylococcus aureus frequently causes infections that are challenging to treat, leading to
high rates of persistent and relapsing infection. Here, to understand how the host …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

There is a clear need for simple resources to improve the quality of antibiotic prescribing
globally. The AWaRe book was designed as a tool to make the antibiotics section of the …

Infective endocarditis is a relatively rare, but deadly cause of sepsis, with an overall mortality
ranging from 20 to 25% in most series. Although the classic clinical classification into …

A positive follow-up blood culture for methicillin-resistant Staphylococcus aureus (MRSA)
while on seemingly appropriate therapy is a common and ominous development. However …

Our review confirms that Staphylococcus aureus represents a special aetiology among all
causes of bloodstream infections. Pending results of platform and larger trials, its distinct …

The last several years have seen an emergence of literature documenting the utility of
combination antimicrobial therapy, particularly in the salvage of refractory methicillin …

Infective endocarditis, osteomyelitis, and osteosynthesis-associated infections are mostly
caused by Gram-positive bacteria. They are often difficult to treat and are associated with a …