Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Abstract Benzo [a] pyrene (B [a] P) is a typical carcinogen associated with increased lung
cancer risk, but the underlying mechanisms remain unclear. This study aimed to investigate …

Individuals differ substantially in their response to pharmacological treatment. Personalized
medicine aspires to embrace these inter-individual differences and customize therapy by …

Today, the rapid development of science and technology and the rapid change in economy
and society are changing the way of life of human beings and affecting the natural, living …

Highly reproducible smoking-associated DNA methylation changes in whole blood have
been reported by many Epigenome-Wide-Association Studies (EWAS). These epigenetic …

Aberrant smoking‐related DNA methylation has been widely investigated as a
carcinogenesis mechanism, but whether the cross‐cancer epigenetic pathways exist …

Lung cancer is the most common cancer and the leading cause of cancer-related morbidity
and mortality worldwide. As early symptoms of lung cancer are minimal and non-specific …

Whether smoking-associated DNA methylation has a causal effect on lung function has not
been thoroughly evaluated. We first investigated the causal effects of 474 smoking …

Identifying genomic regions pertinent to complex traits is a common goal of genome-wide
and epigenome-wide association studies (GWAS and EWAS). GWAS identify causal genetic …