Cancer is a major health burden worldwide, and despite continuous advances in medical
therapies, resistance to standard drugs and adverse effects still represent an important …

Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the
gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy …

Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether
bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells …

FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based
chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer …

Gastrointestinal (GI) side-effects of chemotherapy are a debilitating and often overlooked
clinical hurdle in cancer management. Chemotherapy-induced constipation (CIC) and …

Systems biology provides an opportunity to discover the role that gut microbiota play in
almost all aspects of human health. Existing evidence supports the hypothesis that gut …

Mucositis, also referred to as mucosal barrier injury, is one of the most debilitating side
effects of radiotherapy and chemotherapy treatment. Clinically, mucositis is associated with …

Background Considerable progress has been made in our understanding of the biological
basis for cancer therapy-induced mucosal barrier injury (mucositis). The last formal review of …

Diarrhoea induced by chemotherapy in cancer patients is common, causes notable
morbidity and mortality, and is managed inconsistently. Previous management guidelines …

The adaptor protein CARD9 links detection of fungi by surface receptors to the activation of
the NF-κB pathway. Mice deficient in CARD9 exhibit dysbiosis and are more susceptible to …