Pyrazoline containing compounds as therapeutic targets for neurodegenerative disorders
Pyrazolines are a significant class of heterocyclic compounds with essential biological
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
activities. They are quite stable, which has inspired medicinal chemists to experiment with …
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies
Monoamine oxidase enzyme is necessary for the management of brain functions. It
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update
RKP Tripathi, SR Ayyannan - Medicinal research reviews, 2019 - Wiley Online Library
Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …
indispensable approach of molecular and mechanistic diversity for the discovery of …
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo [d] imidazol-2-yl)
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies
HIGHLIGHTS Many CNS targets are being explored for multi-target drug design New
databases and cheminformatic methods enable prediction of primary pharmaceutical target …
databases and cheminformatic methods enable prediction of primary pharmaceutical target …
Perspective design of chalcones for the management of CNS disorders: a mini-review
B Mathew, DGT Parambi… - CNS & Neurological …, 2019 - ingentaconnect.com
The development of chalcone-based compounds for CNS disorders has been explored by
many research groups. Chalcones are being considered as a potent organic scaffold with …
many research groups. Chalcones are being considered as a potent organic scaffold with …
Monoamine Oxidase Inhibitory Activity: Methyl‐versus Chlorochalcone Derivatives
Numerous studies have shown that chalcones are promising scaffolds for the development
of new monoamine oxidase‐B (MAO‐B) inhibitors. As a continuation of our ongoing …
of new monoamine oxidase‐B (MAO‐B) inhibitors. As a continuation of our ongoing …
Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives
JM Oh, MG Kang, A Hong, JE Park, SH Kim… - International journal of …, 2019 - Elsevier
Abstract Six synthetic (1–6) and six natural (7–12) chalcones were tested for human
monoamine oxidases (hMAOs) and acetylcholinesterase (AChE) inhibitory activities …
monoamine oxidases (hMAOs) and acetylcholinesterase (AChE) inhibitory activities …
Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer's …
Multitarget molecules are considered as an effective way for the treatment of AD, instead of
the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety …
the classic one-drug-one-target strategy because of the multifactorial nature of AD. A variety …
An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors
The selective MAO‐B inhibition is greatly influenced by the degradation pathways of various
biogenic amines. So the design and development of diverse class of MAO‐B inhibitors are …
biogenic amines. So the design and development of diverse class of MAO‐B inhibitors are …