The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

The factor VIII procofactor circulates as a metal ion-dependent heterodimer of a heavy chain
and light chain. Activation of factor VIII results from limited proteolysis catalyzed by thrombin …

Summary Background Factor IX (FIX) is important in the coagulation cascade, being
activated to FIXa on cleavage. Defects in the human F9 gene frequently lead to hemophilia …

Coagulation factor IX (FIX) is a vitamin K dependent protein and its deficiency causes
hemophilia B, an X-linked recessive bleeding disorder. More than 1000 mutations in the F9 …

Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …

Factor VIII, a non-covalent heterodimer comprised of a heavy chain (A1-A2-B domains) and
light chain (A3-C1-C2 domains), circulates as an inactive procofactor in complex with von …

Human enterovirus 71 (EV71) is the major pathogen that causes hand, foot and mouth
disease that particularly affects young children. Growing hand, foot and mouth disease …

Factor IX (FIX) consists of an N-terminal γ-carboxyglutamic acid (Gla) domain followed by
two epidermal growth factor (EGF)-like domains, and the C-terminal serine protease domain …

All naturally occurring amino acids with the exception of glycine contain one or more chiral
carbon atoms and can therefore occur in two different configurations, l (levo, left-handed) …

Mutations in human genes can change the sequence and structure of a protein, impair its
function, and could lead to disease. The increasing number of human protein structures …