Molecular mechanisms underlying neurotransmitter release
J Rizo - Annual Review of Biophysics, 2022 - annualreviews.org
Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …
The mechanisms and functions of synaptic facilitation
SL Jackman, WG Regehr - Neuron, 2017 - cell.com
The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle
TC Südhof - Neuron, 2013 - cell.com
During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …
The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis
Synaptotagmin, complexin, and neuronal SNARE (soluble N-ethylmaleimide sensitive factor
attachment protein receptor) proteins mediate evoked synchronous neurotransmitter …
attachment protein receptor) proteins mediate evoked synchronous neurotransmitter …
The synaptic vesicle cycle revisited: new insights into the modes and mechanisms
NL Chanaday, MA Cousin, I Milosevic… - Journal of …, 2019 - Soc Neuroscience
Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …
The calcium sensor synaptotagmin 7 is required for synaptic facilitation
It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …
use-dependent manner. At synapses with a low initial release probability, closely spaced …
The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones
C Imig, SW Min, S Krinner, M Arancillo, C Rosenmund… - Neuron, 2014 - cell.com
Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …
molecular machinery. We employed hippocampal organotypic slice cultures from mice …
Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis
Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release
Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …