The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

It is controversial whether cells truly die via autophagy or whether—in dying cells—
autophagy is merely an innocent bystander or a well-intentioned 'Good Samaritan'trying to …

Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but
involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as …

Autophagy is a conserved multistep pathway that degrades and recycles damaged
organelles and macromolecules to maintain intracellular homeostasis. The autophagy …