Dihydroartemisinin: a potential drug for the treatment of malignancies and inflammatory diseases

R Yu, G Jin, M Fujimoto - Frontiers in oncology, 2021 - frontiersin.org
Dihydroartemisinin (DHA) has been globally recognized for its efficacy and safety in the
clinical treatment of malaria for decades. Recently, it has been found that DHA inhibits …

Immunosuppression in Malaria: Do Plasmodium falciparum Parasites Hijack the Host?

CL Calle, B Mordmüller, A Singh - Pathogens, 2021 - mdpi.com
Malaria reflects not only a state of immune activation, but also a state of general immune
defect or immunosuppression, of complex etiology that can last longer than the actual …

[HTML][HTML] Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

MSF Soon, HJ Lee, JA Engel, J Straube… - Nature …, 2020 - nature.com
The dynamics of CD4+ T cell memory development remain to be examined at genome
scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its …

[HTML][HTML] Molecular signatures of dengue virus-specific IL-10/IFN-γ co-producing CD4 T cells and their association with dengue disease

Y Tian, G Seumois, LM De-Oliveira-Pinto, J Mateus… - Cell reports, 2019 - cell.com
Dengue virus (DENV) can cause diseases ranging from dengue fever (DF) to more severe
dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Whether antiviral T cells …

The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission

MJ Boyle, P Jagannathan, K Bowen… - Frontiers in …, 2017 - frontiersin.org
Cytokine-producing CD4 T cells have important roles in immunity against Plasmodium
falciparum (Pf) malaria. However, the factors influencing functional differentiation of Pf …

[HTML][HTML] Dihydroartemisinin inhibits melanoma by regulating CTL/Treg anti-tumor immunity and STAT3-mediated apoptosis via IL-10 dependent manner

R Yu, L Jin, F Li, M Fujimoto, Q Wei, Z Lin, X Ren… - Journal of …, 2020 - Elsevier
Background It has been shown that dihydroartemisinin (DHA) is effective in the treatment of
malaria. Recently studies have demonstrated that DHA also regulates tumor cell growth …

In utero priming of highly functional effector T cell responses to human malaria

PM Odorizzi, P Jagannathan, TI McIntyre… - Science translational …, 2018 - science.org
Malaria remains a significant cause of morbidity and mortality worldwide, particularly in
infants and children. Some studies have reported that exposure to malaria antigens in utero …

Dihydroartemisinin alleviates imiquimod-induced psoriasis-like skin lesion in mice involving modulation of IL-23/Th17 Axis

JM Liu, QX Jin, M Fujimoto, FF Li, LB Jin… - Frontiers in …, 2021 - frontiersin.org
Background: Psoriasis is a T help 17 (Th17) cell-mediated chronic inflammatory skin
disease. Recent studies have shown that dihydroartemisinin (DHA) can significantly reduce …

Recent Insights into CD4+ Th Cell Differentiation in Malaria

MSF Soon, A Haque - The Journal of Immunology, 2018 - journals.aai.org
CD4+ Th cell differentiation is crucial for protecting against blood-stage Plasmodium
parasites, the causative agents of malaria. It has been known for decades that more than …

Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood

WE Harrington, SB Kanaan… - The Journal of …, 2017 - academic.oup.com
Background A mother's infection with placental malaria (PM) can affect her child's
susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a …