Mitochondria are best known for their role in the generation of ATP by aerobic respiration.
Yet, research in the past half century has shown that they perform a much larger suite of …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

ABSTRACT TriTrypDB (http://tritrypdb. org) is an integrated database providing access to
genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex …

Intercellular communication between parasites and with host cells provides mechanisms for
parasite development, immune evasion, and disease pathology. Bloodstream African …

Transcription of protein-coding genes in trypanosomes is polycistronic and gene expression
is primarily regulated by post-transcriptional mechanisms. Sequence motifs in the …

The genome of Trypanosoma brucei, the causative agent of African trypanosomiasis, was
published five years ago, yet identification of all genes and their transcripts remains to be …

Comparative studies of the mitochondrial proteome have identified a conserved core of
proteins descended from the α-proteobacterial endosymbiont that gave rise to the …

We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …

Trans-splicing of leader sequences onto the 5′ ends of mRNAs is a widespread
phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we …