As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially
understood despite the fact that environmental causes, risk factors, and specific gene …

Parkinson's disease (PD) pathogenesis may involve the epigenetic control of enhancers that
modify neuronal functions. Here, we comprehensively examine DNA methylation at …

Following the decline of neurogenesis at birth, progenitors of the subventricular zone (SVZ)
remain mostly in a quiescent state in the adult human brain. The mechanisms that regulate …

Parkinson's disease (PD) as a progressive neurodegenerative disorder arises from multiple
genetic and environmental factors. However, underlying pathological mechanisms remain …

An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly
expressed in innate immune cells, yet their role in pathology is not understood. We …

The subventricular zone (SVZ) is the largest and most active germinal zone in the adult
forebrain. Neural stem cells (NSCs) of the SVZ generate olfactory interneurons throughout …

Abstract Three-dimensional (3D) in vitro culture systems using human induced pluripotent
stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in …

Cellular stress responses influence cell fate decisions. Apoptosis and proliferation represent
opposing reactions to cellular stress or damage and may influence distinct health outcomes …