Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During
stimulation, microglia undergo complex morphological changes, including loss of their …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Microtubules are essential for polarized transport in neurons, but how their organization
guides motor proteins to axons or dendrites is unclear. Because different motors recognize …

Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …

Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

The ability of lysosomes to move within the cytoplasm is important for many cellular
functions. This ability is particularly critical in neurons, which comprise vast, highly …

Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …