Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in
refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue …

Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

In clinical trials, the tyrosine kinase inhibitor STI571 has proven highly effective in reducing
leukemic cell burden in chronic myeloid leukemia (CML). The overall sensitivity of CML …

Heat shock proteins (HSPs) HSP27, HSP70 and HSP90 are powerful chaperones. Their
expression is induced in response to a wide variety of physiological and environmental …

The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder arising in the
haemopoietic stem cell (HSC) compartment. This disease is characterised by a reciprocal t …

The Philadelphia chromosome translocation (t [9; 22]) results in the molecular juxtaposition
of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on chromosome 22. BCR …

The Philadelphia chromosome found in virtually all cases of chronic myeloid leukemia
(CML) and in about one third of the cases of adult acute lymphoblastic leukemia is formed by …

Chronic myeloid leukemia (CML) is characterized by the Philadelphia translocation that
fuses BCR sequences from chromosome 22 upstream of the ABL gene on chromosome 9 …

Abstract The translocation (9; 22) gives rise to the p190Bcr-Abl and p210Bcr-Abl tyrosine
kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive …