The skeletal system, which contains bones, joints, tendons, ligaments and other elements,
plays a wide variety of roles in body shaping, support and movement, protection of internal …

Structural disturbances of the subchondral bone are a hallmark of osteoarthritis (OA),
including sclerotic changes, cystic lesions, and osteophyte formation. Osteocytes act as …

Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major
social and economic burdens; however, its underlying molecular mechanisms remain poorly …

Osteoarthritis (OA) is an aging-related degenerative joint disease with a poorly defined
mechanism. Here we report that kindlin-2 is highly expressed in articular chondrocytes and …

The progressive destruction of condylar cartilage is a hallmark of the temporomandibular
joint (TMJ) osteoarthritis (OA); however, its mechanism is incompletely understood. Here, we …

Background The key focal adhesion protein β1 integrin plays an essential role in early
skeletal development. However, roles of β1 integrin expression in osteocytes during the …

Background Cell culture studies demonstrate the importance of β3 integrin in osteocyte
mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of …

Osteoarthritis (OA) is the most common degenerative joint disease affecting the older
populations globally. Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c), a …

Background Our recent studies demonstrate that the focal adhesion protein Kindlin-2 exerts
crucial functions in the mesenchymal stem cells, mature osteoblasts and osteocytes in …

Inflammatory liver diseases are a major cause of morbidity and mortality worldwide;
however, underlying mechanisms are incompletely understood. Here we show that deleting …