Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …
of genes, is required for normal development, and its disruption leads to human disease …
Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development
V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
The health outcomes of human offspring conceived by assisted reproductive technologies (ART)
M Chen, LK Heilbronn - Journal of Developmental Origins of Health …, 2017 - cambridge.org
Concerns have been raised about the health and development of children conceived by
assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked …
assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked …
Sex differences in the intergenerational inheritance of metabolic traits
I Sandovici, DS Fernandez-Twinn, A Hufnagel… - Nature …, 2022 - nature.com
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …
including those in utero, influence our long-term metabolic health. This has been termed …
In vitro fertilization and adverse obstetric and perinatal outcomes
CS Sullivan-Pyke, S Senapati, MA Mainigi… - Seminars in …, 2017 - Elsevier
Most IVF-conceived children are healthy, but IVF has also been associated with adverse
obstetric and perinatal outcomes as well as congenital anomalies. There is also literature …
obstetric and perinatal outcomes as well as congenital anomalies. There is also literature …
Epigenetic changes and assisted reproductive technologies
ABSTRACT Children conceived by Assisted Reproductive Technologies (ART) are at
moderately increased risk for a number of undesirable outcomes, including low birth weight …
moderately increased risk for a number of undesirable outcomes, including low birth weight …
Regulation of maternal–fetal metabolic communication
CE Bowman, Z Arany, MJ Wolfgang - Cellular and molecular life sciences, 2021 - Springer
Pregnancy may be the most nutritionally sensitive stage in the life cycle, and improved
metabolic health during gestation and early postnatal life can reduce the risk of chronic …
metabolic health during gestation and early postnatal life can reduce the risk of chronic …
Epigenetics and the Developmental Origins of Health and Disease: Parental environment signalling to the epigenome, critical time windows and sculpting the adult …
S Safi-Stibler, A Gabory - Seminars in cell & developmental biology, 2020 - Elsevier
Abstract The literature about Developmental Origins of Health and Disease (DOHaD)
studies is considerably growing. Maternal and paternal environment, during all the …
studies is considerably growing. Maternal and paternal environment, during all the …
Epigenetics in the uterine environment: how maternal diet and ART may influence the epigenome in the offspring with long-term health consequences
I Peral-Sanchez, B Hojeij, DA Ojeda… - Genes, 2021 - mdpi.com
The societal burden of non-communicable disease is closely linked with environmental
exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the …
exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the …
Assisted reproductive techniques and risk of Beckwith-Wiedemann syndrome
METHODS: Patients with BWS born in Piemonte, Italy, were identified and matched with the
general demographic data and corresponding regional ART registry. RESULTS: Between …
general demographic data and corresponding regional ART registry. RESULTS: Between …