Current strategies to enhance delivery of drugs across the blood–brain barrier

RI Teleanu, MD Preda, AG Niculescu, O Vladâcenco… - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

SS Hassan, S Samanta, R Dash… - Frontiers in …, 2022 - frontiersin.org
Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

[HTML][HTML] Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm.

V Sharma, DNS Gautam, AF Radu, T Behl, SG Bungau… - Antioxidants, 2022 - mdpi.com
Objectives: Embelia ribes Burm.(E. ribes, Myrsinaceae), also known as Vidanga in
Ayurveda, has been shown to have significant therapeutic benefits on several disorders, and …

Alzheimer's disease as a major public health concern: Role of dietary saponins in mitigating neurodegenerative disorders and their underlying mechanisms

AA Abduljawad, MA Elawad, MEM Elkhalifa, A Ahmed… - Molecules, 2022 - mdpi.com
Saponins are triterpenoid or steroidal glycosides and are an important group of naturally
occurring compounds of plant origin. They exhibit diverse pharmacological potentials …

Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

Multiple health benefits of curcumin and its therapeutic potential

M Shah, W Murad, S Mubin, O Ullah… - … Science and Pollution …, 2022 - Springer
Turmeric, or Curcuma longa as it is formally named, is a multifunctional plant with numerous
names. It was dubbed “the golden spice” and “Indian saffron” not only for its magnificent …

Effect of nutrition in Alzheimer's disease: A systematic review

I Xu Lou, K Ali, Q Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Background and objective Alzheimer's disease (AD) is a progressive neurodegenerative
disease characterized by declining cognitive ability. Currently, there are no effective …

The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile

MT Fatima, AA Bhat, S Nisar, KA Fakhro, ASAS Akil - Heliyon, 2023 - cell.com
Healthy diet is vital to cellular health. The human body succumbs to numerous diseases
which afflict severe economic and psychological burdens on the patient and family …

The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance

MR Islam, MM Rahman, MT Ahasan, N Sarkar… - … Science and Pollution …, 2022 - Springer
The emergence of various diseases during the COVID-19 pandemic made health workers
more attentive, and one of the new pathogens is the black fungus (mucormycosis). As a …

Applications of extracellular vesicles in nervous system disorders: an overview of recent advances

SU Khan, MI Khan, MU Khan, NM Khan, S Bungau… - Bioengineering, 2022 - mdpi.com
Diseases affecting the brain and spinal cord fall under the umbrella term “central nervous
system disease”. Most medications used to treat or prevent chronic diseases of the central …