Organ-on-a-chip: Recent breakthroughs and future prospects

Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

Organs-on-Chips platforms are everywhere: A zoom on biomedical investigation

M Zommiti, N Connil, A Tahrioui, A Groboillot, C Barbey… - Bioengineering, 2022 - mdpi.com
Over the decades, conventional in vitro culture systems and animal models have been used
to study physiology, nutrient or drug metabolisms including mechanical and …

Molecular and biomechanical adaptations to mechanical stretch in cultured myotubes

D Ren, J Song, R Liu, X Zeng, X Yan, Q Zhang… - Frontiers in …, 2021 - frontiersin.org
Myotubes are mature muscle cells that form the basic structural element of skeletal muscle.
When stretching skeletal muscles, myotubes are subjected to passive tension as well. This …

[HTML][HTML] Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives

Y Jiang, T Torun, SM Maffioletti, A Serio… - Experimental Cell …, 2022 - Elsevier
Engineering models of human skeletal muscle tissue provides unique translational
opportunities to investigate and develop therapeutic strategies for acute muscle injuries, and …

Biosyncretic Robots Actuated by Living Materials

L Yang, C Zhang, R Wang, H Qin… - Advanced Materials …, 2024 - Wiley Online Library
In recent years, biosyncretic robots, a novel type of robot that integrates living and artificial
materials, have gained significant attention. Biosyncretic robots are expected to leverage the …

Microfluidics for the study of mechanotransduction

CM Griffith, SA Huang, C Cho, TM Khare… - Journal of physics D …, 2020 - iopscience.iop.org
Mechanical forces regulate a diverse set of biological processes at cellular, tissue, and
organismal length scales. Investigating the cellular and molecular mechanisms that underlie …

Effect of cyclic stretch on tissue maturation in myoblast-laden hydrogel fibers

S Bansai, T Morikura, H Onoe, S Miyata - Micromachines, 2019 - mdpi.com
Engineering of the skeletal muscles has attracted attention for the restoration of damaged
muscles from myopathy, injury, and extraction of malignant tumors. Reconstructing a three …

A microfluidic stretch system upregulates resistance exercise-related pathway

J Ahn, J Kim, JS Jeon, YJ Jang - BioChip Journal, 2022 - Springer
Exercise plays a critical role in maintaining and improving the quantity and quality of skeletal
muscle. Resistance exercise is especially important improves muscle strength and increase …

Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation

WW Hu, YC Chen, CW Tsao, SL Chen… - Bioengineering & …, 2024 - Wiley Online Library
A multifunctional bioreactor was fabricated in this study to investigate the facilitation
efficiency of electrical and mechanical stimulations on myogenic differentiation. This …

Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo

S Lei, Y She, J Zeng, R Chen… - Molecular medicine …, 2019 - spandidos-publications.com
Starvation or severe deprivation of nutrients, which is commonly seen in surgical patients,
can result in catabolic changes in skeletal muscles, such as muscle atrophy. Therefore, it is …