Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Neurodegenerative disorders, such as Alzheimer's disease, are often characterised by the
degeneration of the cholinergic system. Thus, the aim of many treatment regimens is to …

Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …

The main aim of this work was to study the allethrin binding interactions with esterase and its
bioremediation potential using an isolated bacterial strain CW7, identified as Pseudomonas …

Background: Acetylcholinesterase is a serine hydrolase that terminates the action of the
neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Objective: The …

The etiopathology of Alzheimer's disease (AD) is extremely complex and heterogeneous,
often associated with comorbidities. As a result it may be unlikely that AD may be mitigated …

The 3D structure of a complex of the anti‐Alzheimer drug galanthamine with Torpedo
californica acetylcholinesterase is reported. Galanthamine, a tertiary alkaloid extracted from …

Several series of novel chirality descriptors of chemical organic molecules have been
introduced. The descriptors have been developed on the basis of conventional topological …

A simplified synthetic method yielded diverse 2-aminobenzothiazole variants through
sulfonylation and amino group alkylation. Extensive characterization via X-ray diffraction …

Background: Many compounds containing a five-membered heterocyclic ring display
exceptional chemical properties and versatile biological activities. Objective: The objective …