Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia

PB Staber, M Herling, M Bellido… - Blood, The Journal …, 2019 - ashpublications.org
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell neoplasm with a
heterogeneous clinical course. With the advent of novel treatment options that will potentially …

Leukemia cutis

JH Cho-Vega, LJ Medeiros, VG Prieto… - American journal of …, 2008 - academic.oup.com
Leukemia cutis (LC) is a nonspecific term used for cutaneous manifestations of any type of
leukemia. LC has a wide range of cutaneous manifestations, which can make it difficult to …

EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes

JJM Van Dongen, L Lhermitte, S Böttcher, J Almeida… - Leukemia, 2012 - nature.com
Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on
expert opinions, but they have not been validated. Here we present the validated EuroFlow …

Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma

H Sorger, S Dey, PA Vieyra‐Garcia… - EMBO Molecular …, 2022 - embopress.org
Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐
homing mature T‐cells causing severe symptoms and high mortality through chronic …

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

A Schrader, G Crispatzu, S Oberbeck, P Mayer… - Nature …, 2018 - nature.com
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell
malignancy. Here we integrated large-scale profiling data of alterations in gene expression …

Evolution of slow-binding inhibitors targeting histone deacetylase isoforms

A Mukherjee, F Zamani, T Suzuki - Journal of Medicinal Chemistry, 2023 - ACS Publications
Because the overexpression of histone deacetylase enzymes (HDACs) has been linked to
numerous diseases, including various cancers and neurodegenerative disorders, HDAC …

TET2 mutations, myelodysplastic features, and a distinct immunoprofile characterize blastic plasmacytoid dendritic cell neoplasm in the bone marrow

K Alayed, KP Patel, S Konoplev… - American journal of …, 2013 - Wiley Online Library
Distinguishing blastic plasmacytoid dendritic cell neoplasm (BPDCN) from acute myeloid
leukemia (AML) is gaining increased importance because of emerging differences in …

TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state

M Herling, KA Patel, J Khalili, E Schlette, R Kobayashi… - Leukemia, 2006 - nature.com
Expression of the human oncogene TCL1 in transgenic mice produces B-cell tumors that
resemble chronic lymphocytic leukemia (CLL) suggesting its role in B-cell tumorigenesis. To …

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

EI Andersson, S Pützer, B Yadav, O Dufva, S Khan… - Leukemia, 2018 - nature.com
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells
with an urgent need for rationally designed therapies to address its notoriously chemo …

CD4+/CD56+ hematodermic tumor: the features of an evolving entity and its relationship to dendritic cells

M Herling, D Jones - American journal of clinical pathology, 2007 - academic.oup.com
Described herein is the evolution in the diagnosis and classification of tumors that are
variously known as blastic or blastoid natural killer cell lymphoma, CD4+/CD56+ …