Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases

AP Simopoulos - Experimental biology and medicine, 2008 - journals.sagepub.com
Several sources of information suggest that human beings evolved on a diet with a ratio of
omega-6 to omega-3 essential fatty acids (EFA) of~ 1 whereas in Western diets the ratio is …

Alpha‐linolenic acid: an omega‐3 fatty acid with neuroprotective properties—ready for use in the stroke clinic?

N Blondeau, RH Lipsky, M Bourourou… - BioMed research …, 2015 - Wiley Online Library
Alpha‐linolenic acid (ALA) is plant‐based essential omega‐3 polyunsaturated fatty acids
that must be obtained through the diet. This could explain in part why the severe deficiency …

Peroxisome metabolism in cancer

JA Kim - Cells, 2020 - mdpi.com
Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redox
balance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis …

[PDF][PDF] The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease.

AP Simopoulos - Asia Pacific journal of clinical nutrition, 2008 - apjcn.nhri.org.tw
A high omega-6/omega-3 ratio, as is found in today's Western diets, promotes the
pathogenesis of many chronic diseases, including cardiovascular disease. Increased dietary …

Evolutionary aspects of the dietary omega-6/omega-3 fatty acid ratio: medical implications

AP Simopoulos - Evolutionary Thinking in Medicine: From Research to …, 2016 - Springer
Several sources of information suggest that humans evolved on a diet with an equal ratio of
omega-6 (ω-6) to omega-3 (ω-3) fatty acids, whereas in today's Western diet, this ratio is …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

EISA in tandem with ICD to form in situ nanofiber vaccine for enhanced tumor radioimmunotherapy

H Luo, H Cao, H Jia, Y Shang, J Liu… - Advanced …, 2023 - Wiley Online Library
Radiotherapy (RT) can produce a vaccine effect and remodel a tumor microenvironment
(TME) by inducing immunogenic cell death (ICD) and inflammation in tumors. However, RT …

Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs

MD Brown, CA Hart, E Gazi, S Bagley… - British journal of …, 2006 - nature.com
Epidemiological studies have shown not only a relationship between the intake of dietary
lipids and an increased risk of developing metastatic prostate cancer, but also the type of …

Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer

M Hughes-Fulford, CF Li, J Boonyaratanakornkit… - Cancer Research, 2006 - AACR
Essential fatty acids are not only energy-rich molecules; they are also an important
component of the membrane bilayer and recently have been implicated in induction of fatty …