The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery

D Bald, C Villellas, P Lu, A Koul - MBio, 2017 - Am Soc Microbiol
Drug-resistant mycobacterial infections are a serious global health challenge, leading to
high mortality and socioeconomic burdens in developing countries worldwide. New …

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

S Yuan, X Yin, X Meng, JFW Chan, ZW Ye, L Riva… - Nature, 2021 - nature.com
The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a
coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003 …

[HTML][HTML] Artificial intelligence approach fighting COVID-19 with repurposing drugs

YY Ke, TT Peng, TK Yeh, WZ Huang, SE Chang… - Biomedical journal, 2020 - Elsevier
Background The ongoing COVID-19 pandemic has caused more than 193,825 deaths
during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic …

Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance

A Arastehfar, F Daneshnia, N Cabrera… - Nature …, 2023 - nature.com
Candida glabrata is a major fungal pathogen notable for causing recalcitrant infections,
rapid emergence of drug-resistant strains, and its ability to survive and proliferate within …

Population pharmacokinetics and Bayesian dose adjustment to advance TDM of anti-TB drugs

MGG Sturkenboom, AG Märtson, EM Svensson… - Clinical …, 2021 - Springer
Tuberculosis (TB) is still the number one cause of death due to an infectious disease.
Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB …

Clofazimine for the treatment of tuberculosis

JAM Stadler, G Maartens, G Meintjes… - Frontiers in …, 2023 - frontiersin.org
Shorter (6–9 months), fully oral regimens containing new and repurposed drugs are now the
first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long …

Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline

MC Cholo, MT Mothiba, B Fourie… - Journal of Antimicrobial …, 2016 - academic.oup.com
Abstract Drug-resistant (DR)-TB is the major challenge confronting the global TB control
programme, necessitating treatment with second-line anti-TB drugs, often with limited …

New and repurposed drugs for the treatment of active tuberculosis: an update for clinicians

JM Aguilar Diaz, AA Abulfathi, LH Te Brake… - Respiration, 2023 - karger.com
Although tuberculosis (TB) is preventable and curable, the lengthy treatment (generally 6
months), poor patient adherence, high inter-individual variability in pharmacokinetics (PK) …

[HTML][HTML] Recent therapeutic approaches for the management of tuberculosis: Challenges and opportunities

K Patil, S Bagade, S Bonde, S Sharma… - Biomedicine & …, 2018 - Elsevier
Tuberculosis is a highly contagious disease spread by Mycobacterium tuberculosis. It is
responsible for highest numbers of death and soon will surpass the deaths caused by HIV …