Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1, 2, 3-triazoles

S Kumar, B Sharma, V Mehra, V Kumar - European Journal of Medicinal …, 2021 - Elsevier
The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

Current strategies in development of new chromone derivatives with diversified pharmacological activities: A review

NA Mohsin, M Irfan, S Hassan, U Saleem - Pharmaceutical chemistry …, 2020 - Springer
Chromone derivatives possess a spectrum of biological activities. Chromone has been
recognized as a privileged structure for new drug invention and development. Substitution …

Chromone, a privileged scaffold in drug discovery: Developments in the synthesis and bioactivity

AT Benny, SD Arikkatt, CG Vazhappilly… - Mini Reviews in …, 2022 - ingentaconnect.com
Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …

Design, synthesis and antitubercular assessment of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives

RD Bakale, SM Sulakhe, SL Kasare, BP Sathe… - Bioorganic & Medicinal …, 2024 - Elsevier
Abstract A library of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives (7a-q) and
(8a-j) were synthesized and evaluated for their in-vitro antitubercular activity against …

Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation

PS Patil, SL Kasare, NB Haval, VM Khedkar… - Bioorganic & medicinal …, 2020 - Elsevier
In the present study, a series of new isoniazid embedded triazole derivatives have been
synthesized. These compounds were evaluated for their in vitro antitubercular and …

Design and synthesis of new indanol-1, 2, 3-triazole derivatives as potent antitubercular and antimicrobial agents

PS Phatak, RD Bakale, RS Kulkarni, ST Dhumal… - Bioorganic & Medicinal …, 2020 - Elsevier
In a search of new antitubercular agents, herein we have reported a series of new thirty-two
indanol-1, 2, 3-triazole derivatives. The synthesized compounds were screened for their in …

Synthesis of heterocyclic analogs of isoflavone and homoisoflavone based on 3-formylchromone

SS Shatokhin, VA Tuskaev, SC Gagieva… - Russian Chemical …, 2021 - Springer
The review is focused on recent developments of chemistry of synthetic analogs of natural
compounds, isoflavone and homoisoflavone. The possible synthetic strategies to access …

[HTML][HTML] Thiazole, triazole, thio-and semicarbazone derivatives-Promising moieties for drug development for the treatment of tuberculosis

CB Scarim, FR Pavan - European Journal of Medicinal Chemistry Reports, 2021 - Elsevier
Thiazole, triazole, thio and semicarbazones are privileged motifs that act as
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …

Accessing α-Arylated Nitriles via BF3·OEt2 Catalyzed Cyanation of para-Quinone Methides Using tert-Butyl Isocyanide as a Cyanide Source

SR Shirsath, GH Shinde, AC Shaikh… - The Journal of …, 2018 - ACS Publications
BF3· OEt2 catalyzed 1, 6-conjugate addition of tert-butyl isocyanide to para-quinone
methides and fuchsones for the synthesis of α-diaryl and α-triaryl nitriles has been reported …

The first-in-class pyrazole-based dual InhA-VEGFR inhibitors towards integrated antitubercular host-directed therapy

MM Shaaban, M Teleb, HM Ragab, M Singh… - Bioorganic …, 2024 - Elsevier
Several facets of the host response to tuberculosis have been tapped for clinical
investigation, especially targeting angiogenesis mediated by VEGF signaling from infected …