The macroscopic and microscopic anatomy of the oral cavity is complex and unique in the
human body. Soft-tissue structures are in close interaction with mineralized bone, but also …

Chitosan is a chitin-derived biopolymer that has shown great potential for tissue
regeneration and controlled drug delivery. It has numerous qualities that make it attractive …

The essential goal of any adhesive restoration is to achieve a tight and long-lasting
adaptation of the restorative material to enamel and dentin. The key challenge for new …

Biomineralization is a dynamic, complex, lifelong process by which living organisms control
precipitations of inorganic nanocrystals within organic matrices to form unique hybrid …

Collagen mineralization is a biological process in many skeletal elements in the animal
kingdom. Examples of these collagen‐based skeletons are the siliceous spicules of glass …

Background: Dentin is a permeable tubular composite and complex structure, and in weight,
it is composed of 20% organic matrix, 10% water, and 70% hydroxyapatite crystalline matrix …

Objectives The biomodification of dentin is a biomimetic approach, mediated by bioactive
agents, to enhance and reinforce the dentin by locally altering the biochemistry and …

Extracellular vesicles (EV) are small plasma membrane-derived particles released into the
extracellular space by virtually all cell types. Recently, EV have received increased interest …

Several studies have shown that the dentin‐resin interface is unstable due to poor infiltration
of resin monomers into the demineralized dentin matrix. This phenomenon is related to the …

The restoration of dentine lost in deep caries lesions in teeth is a routine and common
treatment that involves the use of inorganic cements based on calcium or silicon-based …