Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates
a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates …

Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the
immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …

Recent reports highlight a new clinical syndrome in children related to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2)—multisystem inflammatory syndrome in …

B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis
(UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n= 145; …

Recently, increasing evidence has suggested the association between gut dysbiosis and
Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis …

PURPOSE AND APPROPRIATE SAMPLE TYPES This 40‐color flow cytometry‐based panel
was developed for in‐depth immunophenotyping of the major cell subsets present in human …

The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …

Genetic studies have revealed many variant loci that are associated with immune-mediated
diseases. To elucidate the disease pathogenesis, it is essential to understand the function of …

Single-cell multiomics data continues to grow at an unprecedented pace. Although several
methods have demonstrated promising results in integrating several data modalities from …