Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
Z Chen, T Shi, L Zhang, P Zhu, M Deng, C Huang, T Hu… - Cancer letters, 2016 - Elsevier
Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …
SLC transporters as therapeutic targets: emerging opportunities
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …
facilitate the transport of a wide array of substrates across biological membranes—have …
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade
ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
Tyrosine kinase inhibitors enhanced the efficacy of conventional chemotherapeutic agent in multidrug resistant cancer cells
S Wu, L Fu - Molecular cancer, 2018 - Springer
Multidrug resistance (MDR) triggered by ATP binding cassette (ABC) transporter such as
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …
ABCB1, ABCC1, ABCG2 limited successful cancer chemotherapy. Unfortunately, no …
Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance
Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …
Repurposing tyrosine kinase inhibitors to overcome multidrug resistance in cancer: a focus on transporters and lysosomal sequestration
M Krchniakova, J Skoda, J Neradil, P Chlapek… - International journal of …, 2020 - mdpi.com
Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies.
Although they were designed to target aberrant tyrosine kinases, they are also intimately …
Although they were designed to target aberrant tyrosine kinases, they are also intimately …
Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells
Overexpression of ABCB1 transporters plays a crucial role in mediating multidrug resistance
(MDR). Therefore, it is important to inhibit ABCB1 activity in order to maintain an effective …
(MDR). Therefore, it is important to inhibit ABCB1 activity in order to maintain an effective …
ABCG2/BCRP: specific and nonspecific modulators
D Peña‐Solórzano, SA Stark, B König… - Medicinal research …, 2017 - Wiley Online Library
Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …
structurally and functionally nonrelated anticancer drugs. This phenomenon has become a …
ABC transporter inhibitors in reversing multidrug resistance to chemotherapy
H Cui, AJ Zhang, M Chen, JJ Liu - Current drug targets, 2015 - ingentaconnect.com
The superfamily of human ATP-binding cassette (ABC) transporters comprises seven
subfamilies (ABCA to G) with 48 members. In addition to their profound physiological and …
subfamilies (ABCA to G) with 48 members. In addition to their profound physiological and …
Repositioning of tyrosine kinase inhibitors as antagonists of ATP-binding cassette transporters in anticancer drug resistance
The phenomenon of multidrug resistance (MDR) has attenuated the efficacy of anticancer
drugs and the possibility of successful cancer chemotherapy. ATP-binding cassette (ABC) …
drugs and the possibility of successful cancer chemotherapy. ATP-binding cassette (ABC) …