Rationale Adolescence is a developmental period of complex neurobiological change and
heightened vulnerability to psychiatric illness. As a result, understanding factors such as sex …

A promising strategy to delay and perhaps prevent Alzheimer's disease (AD) is to identify the
age-related changes that put the brain at risk for the disease. A significant normal age …

This review presents evidence for the idea that the expression of estrogen receptor alpha
and beta (ERα and ERβ) interacts with the level of estradiol (E2) to influence the etiology of …

Neuroprotective effects of phytoestrogen compounds (found in soy) have been
demonstrated in animal research and cell culture studies. In particular, phytoestrogens have …

While the physiology of membrane-initiated estradiol signaling in the nervous system has
remained elusive, a great deal of progress has been made toward understanding the …

The roles of estrogens have been best studied in the breast, breast cancers, and in the
female reproductive tract. However, estrogens have important functions in almost every …

Although several lines of evidence have indicated that menopause is associated with
increased susceptibility to neurological disorders, the mechanisms involved in this …

The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause
of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three …

Familial hemiplegic migraine type 1 (FHM1), a severe migraine with aura variant, is caused
by mutations in the CACNA1A gene. Mutant mice carrying the FHM1 R192Q mutation exhibit …

The expression of the ERα and ERβ estrogen receptors in the hippocampus may be
important in the etiology of age-related cognitive decline. To examine the role of ERα and …