The inflammation-induced dysregulation of reelin homeostasis hypothesis of Alzheimer's disease

BS Reive, V Lau… - Journal of …, 2024 - journals.sagepub.com
Alzheimer's disease (AD) accounts for most dementia cases, but we lack a complete
understanding of the mechanisms responsible for the core pathology associated with the …

Exercise Intervention for Alzheimer's Disease: Unraveling Neurobiological Mechanisms and Assessing Effects

J Ren, H Xiao - Life, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and a major cause of
age-related dementia, characterized by cognitive dysfunction and memory impairment. The …

Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence

N Enduru, BS Fernandes, S Bahrami, Y Dai… - Molecular …, 2024 - nature.com
The occurrence of immune disease comorbidities in Alzheimer's disease (AD) has been
observed in both epidemiological and molecular studies, suggesting a neuroinflammatory …

[HTML][HTML] Genetic overlap between Alzheimer's disease and immune-mediated diseases: An atlas of shared genetic determinants and biological convergence

B Fernandes, N Enduru, S Bahrami, Y Dai… - Research …, 2023 - ncbi.nlm.nih.gov
The occurrence of immune disease comorbidities in Alzheimer's disease (AD) has been
observed in both epidemiological and molecular studies, suggesting a neuroinflammatory …

Identification of candidate biomarkers and pathways associated with multiple sclerosis using bioinformatics and next generation sequencing data analysis

B Vastrad, C Vastrad - bioRxiv, 2023 - biorxiv.org
Multiple sclerosis (MS) is the main reason for disability caused by autoimmunity. However,
effective biomarkers for MS have not been identified. This study explored the molecular …

Exploratory DNA methylation analysis in post-mortem heart tissue of sudden unexplained death

C Sutter, C Haas, PK Bode, J Neubauer… - Clinical …, 2024 - Springer
Background Sudden unexplained death (SUD) is a devastating event in the young. Despite
efforts to identify causal genetic variants, many cases remain unexplained after genetic …

ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway

W Zhai, W Yang, J Ge, X Xiao, K Wu, K She, Y Zhou… - Biology Direct, 2024 - Springer
Background Lung cancer is one of the most frequent cancers and the leading cause of
cancer-related deaths worldwide with poor prognosis. A disintegrin and metalloproteinase …

Amino‐terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains

O Wirths, C Lehnen, M Fricke, I Talucci… - Neuropathology and …, 2024 - Wiley Online Library
Aims The aggregation and deposition of amyloid‐β (Aβ) peptides in the brain is thought to
be the initial driver in the pathogenesis of Alzheimer's disease (AD). Aside from full‐length …

[HTML][HTML] Plasma amyloid-β precursor protein 669–711/amyloid-β1–42 ratio is associated with cognition in Alzheimer's disease

M Noguchi-Shinohara, Y Sakashita, H Nakano… - The Journal of …, 2025 - Elsevier
Plasma amyloid-β (Aβ) markers are significant predictors of Aβ pathology. However, their
prognostic value for cognition in patients with Alzheimer's disease (AD) is unknown. We …

Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons

F Yoshida, R Nagatomo, S Utsunomiya… - Translational …, 2024 - nature.com
Abstract Autism Spectrum Disorder (ASD) is a developmental disorder characterized by
impaired social communication and repetitive behaviors. In recent years, a pharmacological …