Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

TH Bisgaard, KH Allin, L Keefer… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

The role of inflammation in depression and fatigue

CH Lee, F Giuliani - Frontiers in immunology, 2019 - frontiersin.org
Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift

KD Deane, VM Holers - Arthritis & Rheumatology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …

The multiple sclerosis prodrome

N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …

Environmental risk factors for inflammatory bowel disease

N Singh, CN Bernstein - United European gastroenterology …, 2022 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic, progressive immune‐mediated inflammatory
condition of the gastrointestinal tract. Environmental risk factors play a role in developing …

Depression and inflammatory bowel disease: a bidirectional two-sample mendelian randomization study

J Luo, Z Xu, R Noordam, D van Heemst… - Journal of Crohn's and …, 2022 - academic.oup.com
Abstract Background and Aims Observational studies have suggested a bidirectional
association between depression and inflammatory bowel disease [IBD], including Crohn's …

Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of …

AN Ananthakrishnan, GG Kaplan… - The lancet …, 2022 - thelancet.com
Environmental and lifestyle factors play an important role in the natural history of Crohn's
disease and ulcerative colitis. A group of international experts from the International …

Preclinical autoimmune disease: a comparison of rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and type 1 diabetes

G Frazzei, RF van Vollenhoven, BA de Jong… - Frontiers in …, 2022 - frontiersin.org
The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …

From the prodromal stage of multiple sclerosis to disease prevention

RA Marrie, M Allegretta, LF Barcellos, B Bebo… - Nature Reviews …, 2022 - nature.com
A prodrome is an early set of signs or symptoms that indicate the onset of a disease before
more typical symptoms develop. Prodromal stages are well recognized in some neurological …

Efficacy of adjunctive infliximab vs placebo in the treatment of adults with bipolar I/II depression: a randomized clinical trial

RS McIntyre, M Subramaniapillai, Y Lee, Z Pan… - JAMA …, 2019 - jamanetwork.com
Importance To our knowledge, no study has previously evaluated whether individuals with
bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno …