The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-
kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major …

Achalasia of the cardia is associated with an increased risk of esophageal carcinoma. The
real burden of achalasia at the malignancy genesis is still a controversial issue. Therefore …

TP53 genes is one of more important tumor suppressor gene, which acts as a potent
transcription factor with fundamental role in the maintenance of genetic stability. The …

Esophageal cancer affects more than 4, 50,000 persons worldwide, and its incidence has
increased in recent years. It is the eighth most common cancer across the globe. The main …

Trypanosoma cruzi, the etiological agent of Chagas disease, presents a high degree of
intraspecific genetic variability, with possible implications for the clinical forms of the …

This review examines the etiology and pathogenesis of idiopathic achalasia. This disease is
clinically characterized by dysphagia of solids and liquids due to the presence of …

Achalasia is an esophageal motor disorder in which the primary morphologic changes are
found in the myenteric plexus. However, a number of secondary alterations are …

Background: Achalasia and other esophageal dysmotility disorders mimicking achalasia can
be associated with cancer. This study aimed to review the main mechanisms for which …

Idiopathic achalasia and Barrett's esophagus (BE) are preneoplastic conditions of the
esophagus. BE increases the risk of esophageal adenocarcinoma (EAC), while achalasia is …

The prognosis of esophageal squamous cell carcinoma is primarily determined by staging.
Although radiological methods have revealed lymph node metastasis preoperatively, these …