Hypoxic preconditioning protects against ischemic brain injury
FR Sharp, R Ran, A Lu, Y Tang, KI Strauss, T Glass… - NeuroRx, 2004 - Elsevier
Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are
protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia …
protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia …
Early growth response-1 in cardiovascular pathobiology
LM Khachigian - Circulation research, 2006 - Am Heart Assoc
The immediate-early gene product and zinc finger transcription factor early growth response
(Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes …
(Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes …
The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction
K Fan, W Huang, H Qi, C Song, C He, Y Liu… - European journal of …, 2021 - Elsevier
Acute myocardial infarction (AMI) is a type of cardiovascular diseases that severely
threatens human being, but the mechanisms have not been thoroughly clarified. Here, we …
threatens human being, but the mechanisms have not been thoroughly clarified. Here, we …
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat
LL Espey, JAS Richards - Biology of reproduction, 2002 - academic.oup.com
In recent years, there have been a number of efforts to identify genes that are expressed in
mature ovarian follicles in response to an ovulatory dose of LH or its homologue hCG. This …
mature ovarian follicles in response to an ovulatory dose of LH or its homologue hCG. This …
Curcumin, the active constituent of turmeric, inhibits amyloid peptide‐induced cytochemokine gene expression and CCR5‐mediated chemotaxis of THP‐1 monocytes …
Epidemiological studies show reduced risk of Alzheimer's disease (AD) among patients
using non‐steroidal inflammatory drugs (NSAID) indicating the role of inflammation in AD …
using non‐steroidal inflammatory drugs (NSAID) indicating the role of inflammation in AD …
Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular …
E Harja, LG Bucciarelli, Y Lu, DM Stern, YS Zou… - Circulation …, 2004 - Am Heart Assoc
Early growth response-1 (Egr-1) regulates expression of proinflammatory and procoagulant
genes in acute cell stress. Experimental evidence suggested that Egr-1 transcripts were …
genes in acute cell stress. Experimental evidence suggested that Egr-1 transcripts were …
Chemokines and their receptors as markers of allograft rejection and targets for immunosuppression
WW Hancock, L Wang, Q Ye, R Han, I Lee - Current opinion in immunology, 2003 - Elsevier
Although almost every known chemokine and chemokine receptor is expressed at some
stage during development of allograft rejection, mechanistic studies indicate that the actual …
stage during development of allograft rejection, mechanistic studies indicate that the actual …
Peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) activation suppresses ischemic induction of Egr‐1 and its inflammatory gene targets
M Okada, S Fang Yan, DJ Pinsky - The FASEB Journal, 2002 - Wiley Online Library
The peroxisome proliferator‐activated receptor (PPAR) is a nuclear receptor whose
activation regulates metabolism and inflammation. Recent data indicate that the zinc finger …
activation regulates metabolism and inflammation. Recent data indicate that the zinc finger …
Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 …
In Alzheimer's disease (AD) one finds increased deposition of Aβ and also an increased
presence of monocytes/macrophages in the vessel wall and activated microglial cells in the …
presence of monocytes/macrophages in the vessel wall and activated microglial cells in the …
Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo
V Baron, G De Gregorio, A Krones-Herzig, T Virolle… - Oncogene, 2003 - nature.com
Transcription factor early growth response-1 (Egr-1) is a crucial regulator of cell growth,
differentiation and survival. Several observations suggest that Egr-1 is growth promoting in …
differentiation and survival. Several observations suggest that Egr-1 is growth promoting in …