Topical eyedrop application is the preferred route for drug delivery to anterior segment
tissues; however, the challenge of overcoming the eye's anatomical and physiological …

Keratoconjunctivitis sicca (KCS) is a frequent canine ophthalmic disease, resulting from the
deficiency of one or more elements in the precorneal tear film. There are different known …

Breed Predispositions to Disease in Dogs and Cats, Third Edition provides a comprehensive
exploration of current knowledge of breed predispositions based on rigorous examination of …

Keratoconjunctivitis sicca (KCS) is a dysfunction in tear production associated with clinical
signs, which include conjunctival hyperemia, ocular discharge, discomfort, pain, and …

Dry eye disease is a complex ophthalmic disorder that consists of two main subtypes,
aqueous deficient dry eye (ADDE) and evaporative dry eye disease (EDED). Due to the …

Purpose.: Keratoconjunctivitis sicca (KCS) is characterized by inflammation and decreased
production of tears containing increased levels of cytokines. The release occurs in the …

Background Canine keratoconjunctivitis sicca (KCS) is predominantly an immune-mediated
disease. Current therapy of canine KCS is mainly by immunosuppressant, but the …

The purpose of this paper was to determine the efficacy and safety of topical tacrolimus,
compared to cyclosporine, for treating keratoconjunctivitis sicca (KCS) in dogs. This study …

Topical drug delivery is considered as the first option in the treatment of eye diseases. But,
the unique anatomical structure and physiological functions of the eye restricts entry of drugs …

The aim of this study was to evaluate the efficacy of tacrolimus eye drops in alleviating the
clinical symptoms of canine keratoconjunctivitis sicca (KCS) and to compare this efficacy …