Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

Infection, cancer and cardiovascular diseases are the major causes for morbidity and
mortality in the United States according to the Center for Disease Control. The underlying …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

Blood vessel formation is a fundamental process for the development of organism and tissue
regeneration. Of importance, angiogenesis occurring during postnatal development is …

The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is
overexpressed or deregulated in human cancers of diverse origins and plays a key role in …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible
factors (HIFs), HIF-1α and HIF-2α, primarily mediate the transcriptional response to hypoxia …

Aims: Nuclear factor E2-related factor 2 (Nrf2), a key cytoprotective transcription factor,
regulates also proangiogenic mediators, interleukin-8 and heme oxygenase-1 (HO-1) …

Inadequate supply of oxygen (O2) is a hallmark of many diseases, in particular those related
to the cardiovascular system. On the other hand, tissue hypoxia is an important factor …