Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders
which differ in their underlying causes and phenotypes but overlap in patterns of …

Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in
different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non …

Background Asthma exacerbations represent a significant disease burden and are
commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as …

Background IL-10–producing regulatory B (B10) cells potently suppress allergic diseases,
such as contact hypersensitivity (CHS). Splenic B10 cells share overlapping phenotypic …

Background and purpose The persistent influx of neutrophils into the lung and subsequent
tissue damage are characteristics of COPD, cystic fibrosis and acute lung inflammation. VAP …

Several cancer cell types, including chronic lymphocytic leukemia (CLL) and diffuse large B-
cell lymphoma (DLBCL) upregulate antiapoptotic Bcl-2 to cope with oncogenic stress. BH3 …

In order to overcome therapy resistance in cancer, scientists search in nature for novel lead
structures for the development of improved chemotherapeutics. Anthraquinones belong to a …

Background Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus
defined by eosinophil infiltration and tissue remodeling with resulting symptoms of …

Allergic airway diseases are typically characterized by a type 2‐biased inflammation.
Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has …

Bleomycin (BLM) induced cellular damage causes inflammation in the alveolar compartment
and impairment of fibrinolytic system leads to alveolar epithelial cell apoptosis. Here, we …