Radiochemistry for positron emission tomography
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions
X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …
quantitative information about function and metabolism in biological processes in vivo for …
11C-, 12C-, and 13C-cyanation of electron-rich arenes via organic photoredox catalysis
As a non-invasive imaging technology, positron emission tomography (PET) plays a crucial
role in personalized medicine, including early diagnosis, patient screening, and treatment …
role in personalized medicine, including early diagnosis, patient screening, and treatment …
Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging
Purpose Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for
the formation of aromatic C–18 F bonds. This minireview examines proof-of-concept …
the formation of aromatic C–18 F bonds. This minireview examines proof-of-concept …
Room-Temperature Copper-Mediated Radiocyanation of Aryldiazonium Salts and Aryl Iodides via Aryl Radical Intermediates
Radiocyanation is an attractive strategy for incorporating carbon-11 into radiotracer targets,
particularly given the broad scope of acyl moieties accessible from nitriles. Most existing …
particularly given the broad scope of acyl moieties accessible from nitriles. Most existing …
Direct C–H Radiocyanation of Arenes via Organic Photoredox Catalysis
Innovative labeling methods to incorporate the short-lived positron emitter carbon-11 (11C)
into bioactive molecules are attractive for positron emission tomography (PET) tracer …
into bioactive molecules are attractive for positron emission tomography (PET) tracer …
Effect of Water on Direct Radioiodination of Small Molecules/Peptides Using Copper-Mediated Iododeboronation in Water–Alcohol Solvent
Y Kondo, H Kimura, M Sasaki, S Koike, Y Yagi… - Acs Omega, 2023 - ACS Publications
Direct radioiodination of peptides using copper-mediated iododeboronation is a promising
radiosynthetic method for solving issues of classical direct radiolabeling, such as toxicity of …
radiosynthetic method for solving issues of classical direct radiolabeling, such as toxicity of …
Late‐Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO2
A Del Vecchio, F Caillé, A Chevalier… - Angewandte …, 2018 - Wiley Online Library
A robust, click‐chemistry‐inspired procedure for radiolabeling of cyclic ureas was
developed. This protocol, suitable for all carbon isotopes (11C, 13C, 14C), is based on the …
developed. This protocol, suitable for all carbon isotopes (11C, 13C, 14C), is based on the …
Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides
LS Sharninghausen, S Preshlock, ST Joy… - Journal of the …, 2022 - ACS Publications
This report describes a copper-mediated radiocyanation of aryl halides that is applicable to
complex molecules. This transformation tolerates an exceptionally wide range of functional …
complex molecules. This transformation tolerates an exceptionally wide range of functional …
11C‐Cyanation of Aryl Fluorides via Nickel and Lithium Chloride‐Mediated C−F Bond Activation
Z Zhang, T Niwa, K Watanabe… - Angewandte Chemie, 2023 - Wiley Online Library
Aryl fluorides are expected to be useful as radiolabeling precursors due to their chemical
stability and ready availability. However, direct radiolabeling via carbon‐fluorine (C− F) …
stability and ready availability. However, direct radiolabeling via carbon‐fluorine (C− F) …