Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

11C-, 12C-, and 13C-cyanation of electron-rich arenes via organic photoredox catalysis

X Wu, W Chen, N Holmberg-Douglas, GT Bida, X Tu… - Chem, 2023 - cell.com
As a non-invasive imaging technology, positron emission tomography (PET) plays a crucial
role in personalized medicine, including early diagnosis, patient screening, and treatment …

Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging

JS Wright, T Kaur, S Preshlock, SS Tanzey… - Clinical and translational …, 2020 - Springer
Purpose Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for
the formation of aromatic C–18 F bonds. This minireview examines proof-of-concept …

Room-Temperature Copper-Mediated Radiocyanation of Aryldiazonium Salts and Aryl Iodides via Aryl Radical Intermediates

EW Webb, K Cheng, JS Wright, J Cha… - Journal of the …, 2023 - ACS Publications
Radiocyanation is an attractive strategy for incorporating carbon-11 into radiotracer targets,
particularly given the broad scope of acyl moieties accessible from nitriles. Most existing …

Direct C–H Radiocyanation of Arenes via Organic Photoredox Catalysis

W Chen, X Wu, JB McManus, GT Bida, KP Li… - Organic …, 2022 - ACS Publications
Innovative labeling methods to incorporate the short-lived positron emitter carbon-11 (11C)
into bioactive molecules are attractive for positron emission tomography (PET) tracer …

Effect of Water on Direct Radioiodination of Small Molecules/Peptides Using Copper-Mediated Iododeboronation in Water–Alcohol Solvent

Y Kondo, H Kimura, M Sasaki, S Koike, Y Yagi… - Acs Omega, 2023 - ACS Publications
Direct radioiodination of peptides using copper-mediated iododeboronation is a promising
radiosynthetic method for solving issues of classical direct radiolabeling, such as toxicity of …

Late‐Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO2

A Del Vecchio, F Caillé, A Chevalier… - Angewandte …, 2018 - Wiley Online Library
A robust, click‐chemistry‐inspired procedure for radiolabeling of cyclic ureas was
developed. This protocol, suitable for all carbon isotopes (11C, 13C, 14C), is based on the …

Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides

LS Sharninghausen, S Preshlock, ST Joy… - Journal of the …, 2022 - ACS Publications
This report describes a copper-mediated radiocyanation of aryl halides that is applicable to
complex molecules. This transformation tolerates an exceptionally wide range of functional …

11C‐Cyanation of Aryl Fluorides via Nickel and Lithium Chloride‐Mediated C−F Bond Activation

Z Zhang, T Niwa, K Watanabe… - Angewandte Chemie, 2023 - Wiley Online Library
Aryl fluorides are expected to be useful as radiolabeling precursors due to their chemical
stability and ready availability. However, direct radiolabeling via carbon‐fluorine (C− F) …