Tissue-engineered vascular grafts for use in the treatment of congenital heart disease: from the bench to the clinic and back again

JT Patterson, T Gilliland, MW Maxfield… - Regenerative …, 2012 - Taylor & Francis
Since the first tissue-engineered vascular graft (TEVG) was implanted in a child over a
decade ago, growth in the field of vascular tissue engineering has been driven by clinical …

Thromboembolic problems after the Fontan operation

P Monagle, TR Karl - Seminars in Thoracic and Cardiovascular Surgery …, 2002 - Elsevier
One of the major causes of morbidity and mortality after the Fontan operation is
thromboembolic events (TE). To assess the current knowledge of TE after Fontan surgery, a …

Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling

JD Roh, R Sawh-Martinez… - Proceedings of the …, 2010 - National Acad Sciences
Biodegradable scaffolds seeded with bone marrow mononuclear cells (BMCs) are the
earliest tissue-engineered vascular grafts (TEVGs) to be used clinically. These TEVGs …

Spontaneous reversal of stenosis in tissue-engineered vascular grafts

JD Drews, VK Pepper, CA Best, JM Szafron… - Science translational …, 2020 - science.org
We developed a tissue-engineered vascular graft (TEVG) for use in children and present
results of a US Food and Drug Administration (FDA)–approved clinical trial evaluating this …

[HTML][HTML] Evaluation of a novel Y-shaped extracardiac Fontan baffle using computational fluid dynamics

AL Marsden, AJ Bernstein, VM Reddy… - The Journal of Thoracic …, 2009 - Elsevier
OBJECTIVES: The objective of this work is to evaluate the hemodynamic performance of a
new Y-graft modification of the extracardiac conduit Fontan operation. The performance of …

Tissue-engineered vascular grafts demonstrate evidence of growth and development when implanted in a juvenile animal model

MP Brennan, A Dardik, N Hibino, JD Roh… - Annals of …, 2008 - journals.lww.com
Objective: To evaluate the growth potential of a tissue-engineered vascular graft (TEVG) in a
juvenile animal model. Methods: Polyglycolic acid nonwoven mesh tubes (3-cm length, 1.3 …

Optimal conduit size of the extracardiac Fontan operation based on energy loss and flow stagnation

K Itatani, K Miyaji, T Tomoyasu, Y Nakahata… - The annals of thoracic …, 2009 - Elsevier
BACKGROUND: In the extracardiac Fontan operation, larger conduits are used when
considering the patients' growth rate. However, larger conduits may cause inefficient flow …

[HTML][HTML] Trends in Fontan surgery and risk factors for early adverse outcomes after Fontan surgery: the Australia and New Zealand Fontan Registry experience

AJ Iyengar, DS Winlaw, JC Galati… - The Journal of thoracic …, 2014 - Elsevier
Objectives This study examined changes in practice and analyzed risk factors for adverse
early outcomes after Fontan surgery through use of a binational, population-based registry …

[HTML][HTML] The modern Fontan operation shows no increase in mortality out to 20 years: a new paradigm

RJ Dabal, JK Kirklin, M Kukreja, RN Brown… - The Journal of thoracic …, 2014 - Elsevier
Objective Dating back to the first published report of the Fontan circulation in 1971, multiple
studies have examined the long-term results of this standard procedure for palliation of …

Tissue engineering of vascular grafts: A case report from bench to bedside and back

T Breuer, M Jimenez, JD Humphrey… - … , and vascular biology, 2023 - Am Heart Assoc
For over 25 years, our group has used regenerative medicine strategies to develop
improved biomaterials for use in congenital heart surgery. Among other applications, we …