Peptide transport is currently a prominent topic in membrane research. The transport
proteins involved are under intense investigation because of their physiological importance …

A large amount of absorptive intestinal membrane transporters play an important part in
absorption and distribution of several nutrients, drugs and prodrugs. The present paper …

Nucleoside analogues are widely used for the treatment of antiviral infections and
anticancer chemotherapy. However, many nucleoside analogues suffer from poor oral …

The intestinal epithelium of adult humans acts as a differentially permeable barrier that
separates the potentially harmful contents of the lumen from the underlying tissues. Any …

The human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of
dipeptides, tripeptides, and many peptidomimetic drugs. In this study, a large number of …

Peptide transporter 1, PEPT1, of the mammalian enterocyte is presently under intense
investigation in many laboratories because of its nutritional importance in the absorption of …

Gemcitabine, a clinically effective nucleoside anticancer agent, is a polar drug with low
membrane permeability and is administered intravenously. Further, extensive degradation of …

Amino acid ester prodrugs of 2-bromo-5, 6-dichloro-1-(β-d-ribofuranosyl) benzimidazole
(BDCRB) were synthesized and evaluated for their affinity for hPEPT1, an intestinal …

Antibacterial drug discovery has benefitted from the availability of a large number of genome
sequences for target selection and new assay formats for inhibitor identification. Until …

The effects of low-molecular-weight (< 1000 g/mol) chemicals on biosystems ranging from
membranes to organisms are of interest in medicinal chemistry, chemical biology …