Using rotenone to model Parkinson's disease in mice: a review of the role of pharmacokinetics
Rotenone is a naturally occurring toxin that inhibits complex I of the mitochondrial electron
transport chain. Several epidemiological studies have shown an increased risk of …
transport chain. Several epidemiological studies have shown an increased risk of …
Therapeutic potential of plant oxylipins
T Savchenko, E Degtyaryov, Y Radzyukevich… - International Journal of …, 2022 - mdpi.com
For immobile plants, the main means of protection against adverse environmental factors is
the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and …
the biosynthesis of various secondary (specialized) metabolites. The extreme diversity and …
Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model
D Zhang, S Li, L Hou, L Jing, Z Ruan, B Peng… - Journal of …, 2021 - Springer
Background Cognitive decline occurs frequently in Parkinson's disease (PD), which greatly
decreases the quality of life of patients. However, the mechanisms remain to be investigated …
decreases the quality of life of patients. However, the mechanisms remain to be investigated …
[HTML][HTML] Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced …
S Ahmed, MM El-Sayed, MA Kandeil… - Saudi Pharmaceutical …, 2022 - Elsevier
Abstract Sodium-glucose co-transporter 2 (SGLT 2) inhibitors are a relatively new
antidiabetic drug with antioxidant and anti-inflammatory properties. Therefore, this study …
antidiabetic drug with antioxidant and anti-inflammatory properties. Therefore, this study …
Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB …
The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …
Ginkgo biloba protects striatal neurodegeneration and gut phagoinflammatory damage in rotenone‐induced mice model of Parkinson's disease: Role of executioner …
Asymptomatic and early clinical stages of Parkinson's disease (PD) have been linked with
comorbid non‐motor symptoms including dysfunction of the gastrointestinal (GI) tract …
comorbid non‐motor symptoms including dysfunction of the gastrointestinal (GI) tract …
Neuroprotective effect of phloretin in rotenone-induced mice model of Parkinson's disease: Modulating mTOR-NRF2-p62 mediated autophagy-oxidative stress …
Background: Parkinson's disease (PD) is an age-related progressive multifactorial,
neurodegenerative disease. The autophagy and Keap1-Nrf2 axis system are both …
neurodegenerative disease. The autophagy and Keap1-Nrf2 axis system are both …
Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation
Parkinson's disease (PD) is characterized by motor and non-motor symptoms associated
with dopaminergic and non-dopaminergic injury. Vortioxetine is a multimodal serotonergic …
with dopaminergic and non-dopaminergic injury. Vortioxetine is a multimodal serotonergic …
Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1–42 through Nrf2/HO-1 and NF-κB signaling pathway in mice
SY Jin, X Wang, XT Xiang, YM Wu, J Hu, YY Li… - International …, 2021 - Elsevier
The accumulation of amyloid beta (Aβ) in the brain is thought to be associated with cognitive
deficits in Alzheimer's disease (AD). However, current methods to combat Aβ neurotoxicity …
deficits in Alzheimer's disease (AD). However, current methods to combat Aβ neurotoxicity …
Repeated endosulfan exposure induces changes in neurochemicals, decreases ATPase transmembrane ionic-pumps, and increased oxidative/nitrosative stress in …
Neurochemical and ATPase deregulations play important role in toxicant-induced
neurodegeneration. Previous studies have shown that loss of ATPase ionic-pumps alters …
neurodegeneration. Previous studies have shown that loss of ATPase ionic-pumps alters …