The spatio-temporal behaviour of the intracellular calcium concentration is both
physiologically important and theoretically complex, and this has led to a large body of joint …

Many ion channels spontaneously switch between different levels of activity. Although this
behaviour known as modal gating has been observed for a long time it is currently not well …

Experimental records of single molecules or ion channels from fluorescence microscopy and
patch-clamp electrophysiology often include high-frequency noise and baseline fluctuations …

Tightly clustered inositol trisphosphate receptors (IP 3 Rs) control localized Ca 2+ liberation
from the endoplasmic reticulum to generate repetitive Ca 2+ puffs. Distributions of the …

Intracellular accumulation of oligomeric forms of β amyloid (Aβ) are now believed to play a
key role in the earliest phase of Alzheimer's disease (AD) as their rise correlates well with …

The combination of highly resolved fluorescent imaging methods and detailed mathematical
modeling is a powerful approach towards the understanding of a wide range of Ca 2+ …

AIM To detect the expression of type I inositol 1, 4, 5-trisphosphate receptor (IP 3 RI) in the
kidney of rats with hepatorenal syndrome (HRS). METHODS One hundred and twenty-five …

The ability of cells to receive and process chemical information is fundamental to the
function of biological systems. Cell responses to salient chemical cues are characteristically …

In this thesis, a number of biophysically relevant models will be introduced, to explain open
problems in biophysics. Some of the key pathways that are modeled include potential …