Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
D Hendriks, JF Brouwers, K Hamer, MH Geurts… - Nature …, 2023 - nature.com
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the
paucity of human-relevant models for target discovery and compound screening. Here we …
paucity of human-relevant models for target discovery and compound screening. Here we …
[HTML][HTML] Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
A Marsee, FJM Roos, MMA Verstegen, F Roos… - Cell stem cell, 2021 - cell.com
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …
development, disease, and regeneration. As organoid research expands, the need for clear …
Chronic inflammation in non-alcoholic steatohepatitis: molecular mechanisms and therapeutic strategies
C Luci, M Bourinet, PS Leclère, R Anty… - Frontiers in …, 2020 - frontiersin.org
Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …
En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Genotype-phenotype associations for common diseases are often compounded by
pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of …
pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of …
Modelling metabolic diseases and drug response using stem cells and organoids
Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …
major threat to health in the modern world, but efforts to understand the underlying …
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
S Wang, SL Friedman - Science translational medicine, 2023 - science.org
Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …
that poses a global health threat because of its potential to progress to advanced fibrosis …
In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal
PA Soret, J Magusto, C Housset… - Journal of clinical medicine, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
A critical perspective on 3D liver models for drug metabolism and toxicology studies
AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …