Codon optimality, bias and usage in translation and mRNA decay
G Hanson, J Coller - Nature reviews Molecular cell biology, 2018 - nature.com
The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …
In vivo aspects of protein folding and quality control
BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
KC Stein, F Morales-Polanco, J van der Lienden… - Nature, 2022 - nature.com
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …
Design of a synthetic yeast genome
We describe complete design of a synthetic eukaryotic genome, Sc2. 0, a highly modified
Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of …
Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of …
[HTML][HTML] Codon optimality is a major determinant of mRNA stability
Summary mRNA degradation represents a critical regulated step in gene expression.
Although the major pathways in turnover have been identified, accounting for disparate half …
Although the major pathways in turnover have been identified, accounting for disparate half …
Codon bias as a means to fine-tune gene expression
The redundancy of the genetic code implies that most amino acids are encoded by multiple
synonymous codons. In all domains of life, a biased frequency of synonymous codons is …
synonymous codons. In all domains of life, a biased frequency of synonymous codons is …
Synonymous but not silent: the codon usage code for gene expression and protein folding
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …
Although synonymous mutations were previously thought to be silent, a large body of …
Codon usage influences the local rate of translation elongation to regulate co-translational protein folding
Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
Codon usage is an important determinant of gene expression levels largely through its effects on transcription
Codon usage biases are found in all eukaryotic and prokaryotic genomes, and preferred
codons are more frequently used in highly expressed genes. The effects of codon usage on …
codons are more frequently used in highly expressed genes. The effects of codon usage on …
Optimization of codon translation rates via tRNA modifications maintains proteome integrity
DD Nedialkova, SA Leidel - Cell, 2015 - cell.com
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome
transit along a given mRNA can influence nascent chain folding, but the extent to which …
transit along a given mRNA can influence nascent chain folding, but the extent to which …